Linked Life Data

7970871

Source:http://linkedlifedata.com/resource/pubmed/id/7970871

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-12-6
pubmed:abstractText
Nippostrongylus brasiliensis worms obtained from the stable phase of a primary infection ('normal' worms) are able to establish and survive in naïve recipient rats into which they have been adoptively transferred, whereas those obtained at the time of expulsion ('damaged' worms) are rapidly expelled. Expulsion is associated with quantitative/qualitative goblet cell changes. Thus, N. brasiliensis adult worms seem to stimulate the expulsion process only after being 'damaged' by the host's immunity, whereas it is possible that 'normal' worms may inhibit the expulsion process. To see whether 'normal' worms have such inhibitory effects, the fate of concurrently implanted 'normal' and 'damaged' worms was examined with reference to goblet cell changes in the intestine. By using either male or female worms as 'normal' or 'damaged' populations, it was possible to determine the origin of worms remaining in the intestine. The results show that not only 'normal' worms but also 'damaged' worms, which would normally be expelled, remained in the intestines of the recipients on Day five. Goblet cell hyperplasia and alteration of terminal sugars of mucins, which was induced within five days after implantation of 'damaged' worms, were completely inhibited by the concurrent presence of 'normal' worms. The inhibitory effects of 'normal' worms were destroyed when they were killed by heating before implantation. Possible mechanisms leading to expulsion of N. brasiliensis are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0141-9838
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Inhibitory effects of concurrently present 'normal' Nippostrongylus brasiliensis worms on expulsion of 'damaged' worms and associated goblet cell changes in rats.
pubmed:affiliation
Department of Parasitology, Miyazaki Medical College, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't