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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1994-11-28
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pubmed:abstractText |
A double-blind, randomized, placebo-controlled study was conducted to determine the effect of nifedipine on early renal allograft function when added to a triple therapy immunosuppression regime comprising low-dose cyclosporin (CsA), prednisolone and azathioprine. Fifty adult cadaveric renal allograft recipients were randomized to placebo (group P n = 17), nifedipine 10 mg preoperatively and 20 mg b.d. postoperatively for 48 h, followed by matching placebo for 3 months (group NS n = 16) or nifedipine 10 mg preoperatively and 20 mg b.d. postoperatively for 3 months (group NL n = 17). Donor and recipient exclusion criteria included recent calcium antagonist treatment. At 3 months after transplantation mean GFR adjusted for graft loss was significantly higher in group NL than in NS (mean +/- SD 61 +/- 28 versus 34 +/- 25 ml/min/1.73 m2; P < 0.05), group P being intermediate (45 +/- 34 ml/min/1.73 m2). Similarly, effective renal blood flow (ERBF) at 3 months was higher in group NL than in groups P and NS (mean +/- SD 351 +/- 175 versus 216 +/- 166 and 220 +/- 162 ml/min/1.73 m2; P < 0.05). The differences were not significant by 6 months post-transplantation. This study suggests that oral nifedipine commenced preoperatively and continued for 3 months following transplantation has beneficial effects on early renal allograft function when incorporated as part of an immunotherapy regimen based on cyclosporin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0931-0509
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
800-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7970122-Adult,
pubmed-meshheading:7970122-Cyclosporine,
pubmed-meshheading:7970122-Female,
pubmed-meshheading:7970122-Glomerulonephritis,
pubmed-meshheading:7970122-Graft Rejection,
pubmed-meshheading:7970122-Graft Survival,
pubmed-meshheading:7970122-Humans,
pubmed-meshheading:7970122-Kidney,
pubmed-meshheading:7970122-Kidney Transplantation,
pubmed-meshheading:7970122-Male,
pubmed-meshheading:7970122-Middle Aged,
pubmed-meshheading:7970122-Nifedipine,
pubmed-meshheading:7970122-Postoperative Complications,
pubmed-meshheading:7970122-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
A double-blind, randomized, placebo-controlled study of nifedipine on early renal allograft function.
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pubmed:affiliation |
Royal London Hospital, Whitechapel, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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