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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-4
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pubmed:dateCreated |
1994-12-7
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pubmed:abstractText |
Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex IV,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, ribosomal, 12S
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7968373-Actins,
pubmed-meshheading:7968373-Aged,
pubmed-meshheading:7968373-Aged, 80 and over,
pubmed-meshheading:7968373-Alzheimer Disease,
pubmed-meshheading:7968373-Autopsy,
pubmed-meshheading:7968373-Biological Markers,
pubmed-meshheading:7968373-Blotting, Northern,
pubmed-meshheading:7968373-Brain,
pubmed-meshheading:7968373-Electron Transport Complex IV,
pubmed-meshheading:7968373-Female,
pubmed-meshheading:7968373-Gene Expression,
pubmed-meshheading:7968373-Humans,
pubmed-meshheading:7968373-L-Lactate Dehydrogenase,
pubmed-meshheading:7968373-Macromolecular Substances,
pubmed-meshheading:7968373-Male,
pubmed-meshheading:7968373-Mitochondria,
pubmed-meshheading:7968373-RNA, Messenger,
pubmed-meshheading:7968373-RNA, Ribosomal,
pubmed-meshheading:7968373-Reference Values
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pubmed:year |
1994
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pubmed:articleTitle |
Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.
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pubmed:affiliation |
Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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