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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1994-12-16
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pubmed:abstractText |
Indole-3-carbinol (I3C) and related compounds have been identified in vegetables of the Brassica genus. I3C and its acid-derived condensation product, indolo[3,2-b]carbazole (ICZ), bind to the aryl hydrocarbon (Ah) receptor and induce CYP1A1/1A2 gene expression in both in vivo and in vitro models. I3C also inhibits mammary tumor development in rodent models.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1758-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7966413-Base Sequence,
pubmed-meshheading:7966413-Breast Neoplasms,
pubmed-meshheading:7966413-Carbazoles,
pubmed-meshheading:7966413-Cytochrome P-450 CYP1A1,
pubmed-meshheading:7966413-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7966413-Enzyme Induction,
pubmed-meshheading:7966413-Estrogen Antagonists,
pubmed-meshheading:7966413-Humans,
pubmed-meshheading:7966413-Indoles,
pubmed-meshheading:7966413-Molecular Sequence Data,
pubmed-meshheading:7966413-Oxidoreductases,
pubmed-meshheading:7966413-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity.
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pubmed:affiliation |
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station 77843-4466.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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