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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1994-12-16
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pubmed:abstractText |
Homologous SIVsm stocks were generated by passage of a macaque isolate of SIVsm (SIVsm/E660) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIVsmH4 clone and were challenged with either cell-free stock. Only vaccinees challenged with virus generated in human cells were protected from infection. This confirms the species-specificity of whole inactivated vaccine-mediated protection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0047-2565
|
pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7966237-Animals,
pubmed-meshheading:7966237-Antibodies, Viral,
pubmed-meshheading:7966237-Cell Line,
pubmed-meshheading:7966237-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7966237-Humans,
pubmed-meshheading:7966237-Macaca mulatta,
pubmed-meshheading:7966237-SAIDS Vaccines,
pubmed-meshheading:7966237-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7966237-Simian immunodeficiency virus,
pubmed-meshheading:7966237-Time Factors,
pubmed-meshheading:7966237-Viremia
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pubmed:articleTitle |
Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells.
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pubmed:affiliation |
Immunodeficiency Viruses Section, NIAID, NIH, Rockville, MD 20852.
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pubmed:publicationType |
Journal Article,
Comparative Study
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