Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
|
pubmed:dateCreated |
1994-12-20
|
pubmed:abstractText |
The synthesis of the indolequinones 8 and 9 starting from methyl 4-(benzyloxy)-5-methoxy-indole-2-carboxylate (10) is described. The methoxy group in the indolequinones 1, 2, 4, 5, and 7-9 can be displaced by various nitrogen nucleophiles (ammonia, 2-methoxyethylamine, aziridine, 2-methylaziridine, pyrrolidine) in 22-88% yield. The resulting amino-substituted quinones, together with their methoxy precursors, were studied by cyclic voltammetry to determine their reduction potentials, which, in DMF solution, lie in the range -1.355 to -1.597 V (vs ferrocene). The cytotoxicity of the compounds towards aerobic and hypoxic mammalian cells was also determined; in general, under aerobic conditions, the cyclopropamitosenes are more toxic than the corresponding pyrrolo[1,2-a]indolequinones, which are in turn more toxic than the simple 1,2-dimethylindolequinones, with many of the compounds in each series showing greater toxicity toward hypoxic cells.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
28
|
pubmed:volume |
37
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3834-43
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7966141-Animals,
pubmed-meshheading:7966141-Cell Division,
pubmed-meshheading:7966141-Cells, Cultured,
pubmed-meshheading:7966141-Cricetinae,
pubmed-meshheading:7966141-Cricetulus,
pubmed-meshheading:7966141-Electrochemistry,
pubmed-meshheading:7966141-Indoles,
pubmed-meshheading:7966141-Mitomycins,
pubmed-meshheading:7966141-Oxidation-Reduction,
pubmed-meshheading:7966141-Quinones
|
pubmed:year |
1994
|
pubmed:articleTitle |
Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis, electrochemistry, and biological activity of 7-substituted cyclopropamitosenes and related indolequinones.
|
pubmed:affiliation |
Department of Chemistry, Loughborough University of Technology, Leicestershire, U.K.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|