Linked Life Data

7965056

Source:http://linkedlifedata.com/resource/pubmed/id/7965056

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pubmed-article:7965056pubmed:abstractTextThe rho 2 subunit, a novel GABA receptor subunit, has been cloned from a human retinal complementary DNA library. This subunit shares 74% amino acid sequence identity with the rho 1 subunit that forms homooligomeric bicuculline-, barbiturate-, and benzodiazepine-insensitive GABA receptors. The rho 2 subunit also forms homooligomeric GABA-activated chloride channels when expressed in Xenopus oocytes. The amplitudes of the whole-cell currents of rho 2 receptors are always smaller than those of rho 1 receptors, but the affinity and cooperativity of GABA are very similar. Like the rho 1 subunit, the currents generated by rho 2 are insensitive to GABAA receptor modulators including bicuculline, hexobarbital, and diazepam and can be reversibly inhibited by ZnCl2. Homooligomeric rho 2 and rho 1 receptors are less sensitive to muscimol and picrotoxin, and desensitize slower than GABAA receptors. These data demonstrate that homooligomeric receptors formed by rho 2 and rho 1 subunits have a number of electrophysiologic and pharmacologic characteristics that differ from receptors formed by GABAA receptor subunits. The distinctive properties of rho receptors are very similar to those of bicuculline-insensitive GABA-gated chloride channels identified in retina, suggesting a molecular basis for this form of GABA receptor in visual pathways.lld:pubmed
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pubmed-article:7965056pubmed:articleTitleA novel gamma-aminobutyric acid receptor subunit (rho 2) cloned from human retina forms bicuculline-insensitive homooligomeric receptors in Xenopus oocytes.lld:pubmed
pubmed-article:7965056pubmed:affiliationDepartment of Pediatrics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205.lld:pubmed
pubmed-article:7965056pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7965056pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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