|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-12-28
|
|
pubmed:abstractText |
Screening a small cell lung cancer cDNA library with serum from a patient with antibody-associated paraneoplastic sensory neuronopathy (Anti-Hu syndrome) resulted in the isolation of a cDNA clone encoding the Ro-52 kD antigen. The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjögren's syndrome and systemic lupus erythematosus. Further investigation revealed that the sera of only a small percentage (4%) of patients with the Hu syndrome reacted with Ro-52 kD antigen. The cross-reactivity may result from a domain of high homology between Ro-52 kD and HuD antigen. These results emphasize the necessity of using recombinant antigens whenever possible when assaying for assaying for specific antibodies.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/ELAVL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hu Paraneoplastic...,
http://linkedlifedata.com/resource/pubmed/chemical/Molecular Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Cytoplasmic,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/SS-A antigen,
http://linkedlifedata.com/resource/pubmed/chemical/TROVE2 protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0167-594X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
105-12
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7964985-Amino Acid Sequence,
pubmed-meshheading:7964985-Antibodies,
pubmed-meshheading:7964985-Autoantigens,
pubmed-meshheading:7964985-Base Sequence,
pubmed-meshheading:7964985-Blood,
pubmed-meshheading:7964985-Cloning, Molecular,
pubmed-meshheading:7964985-DNA, Complementary,
pubmed-meshheading:7964985-Encephalomyelitis,
pubmed-meshheading:7964985-Hu Paraneoplastic Encephalomyelitis Antigens,
pubmed-meshheading:7964985-Humans,
pubmed-meshheading:7964985-Molecular Probes,
pubmed-meshheading:7964985-Molecular Sequence Data,
pubmed-meshheading:7964985-Molecular Weight,
pubmed-meshheading:7964985-Nerve Tissue Proteins,
pubmed-meshheading:7964985-Paraneoplastic Syndromes,
pubmed-meshheading:7964985-RNA, Small Cytoplasmic,
pubmed-meshheading:7964985-RNA-Binding Proteins,
pubmed-meshheading:7964985-Recombinant Fusion Proteins,
pubmed-meshheading:7964985-Ribonucleoproteins,
pubmed-meshheading:7964985-Sensation Disorders
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuronopathy recognize the Ro-52K antigen.
|
|
pubmed:affiliation |
Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, N.Y., N.Y.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
