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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1994-12-6
|
| pubmed:abstractText |
A woman with definite multiple sclerosis (MS) and mitochondrial myopathy is described. There were widespread white matter lesions on magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) abnormalities and evoked response changes. Muscle biopsy showed ragged red fibres (RRFs) and cytochrome c oxidase (CoX) deficiency. Southern blot analysis revealed a large deletion of mitochondrial DNA (mtDNA). The patient may be affected by two unrelated diseases, MS and mitochondrial myopathy, but this combination has never previously been reported.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0340-5354
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
241
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7964921-Biopsy,
pubmed-meshheading:7964921-Blotting, Southern,
pubmed-meshheading:7964921-DNA, Mitochondrial,
pubmed-meshheading:7964921-Female,
pubmed-meshheading:7964921-Gene Deletion,
pubmed-meshheading:7964921-Humans,
pubmed-meshheading:7964921-Magnetic Resonance Imaging,
pubmed-meshheading:7964921-Middle Aged,
pubmed-meshheading:7964921-Mitochondrial Myopathies,
pubmed-meshheading:7964921-Multiple Sclerosis,
pubmed-meshheading:7964921-Muscle, Skeletal
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Multiple sclerosis and mitochondrial myopathy: an unusual combination of diseases.
|
| pubmed:affiliation |
Istituto di Clinica Neurologica, Università degli Studi di Milano, Italy.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|