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| pubmed-article:7964506 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7964506 | lifeskim:mentions | umls-concept:C1527180 | lld:lifeskim |
| pubmed-article:7964506 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7964506 | pubmed:dateCreated | 1994-12-23 | lld:pubmed |
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| pubmed-article:7964506 | pubmed:abstractText | To examine T cell receptor (TCR) diversity involved in the memory response to a persistent human pathogen, we determined nucleotide sequences encoding TCR-alpha and -beta chains from HLA-B8-restricted, CD8+ cytotoxic T cell clones specific for an immunodominant epitope (FLRGRAYGL) in Epstein-Barr virus (EBV) nuclear antigen 3. Herein, we show that identical TCR protein sequences are used by clones from each of four healthy unrelated virus carriers; a clone from a fifth varied conservatively at only two residues. This dominant selection of alpha and beta chain rearrangements suggest that a persistent viral infection can select for a highly focused memory response and indicates a strong bias in gene segment usage and recombination. A novel double-step semiquantitative polymerase chain reaction (PCR) procedure and direct sequencing of amplified TCR cDNA from fresh lymphocytes derived from three HLA-B8 individuals detected transcripts specific for the conserved beta chain in an EBV-seropositive donor but not in two seronegative donors. This report describes an unprecedented degree of conservation in TCR selected in response to a natural persistent infection. | lld:pubmed |
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| pubmed-article:7964506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7964506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7964506 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7964506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7964506 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7964506 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:MiskoI SIS | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:MossD JDJ | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:KieffEE | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:SculleyT BTB | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:SchmidtC WCW | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:DoolanD LDL | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:KurillaM GMG | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:SilinsS LSL | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:ArgaetV PVP | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:SuhrbierAA | lld:pubmed |
| pubmed-article:7964506 | pubmed:author | pubmed-author:BurrowsS RSR | lld:pubmed |
| pubmed-article:7964506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7964506 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7964506 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:7964506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7964506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7964506 | pubmed:pagination | 2335-40 | lld:pubmed |
| pubmed-article:7964506 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7964506 | pubmed:meshHeading | pubmed-meshheading:7964506-... | lld:pubmed |
| pubmed-article:7964506 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7964506 | pubmed:articleTitle | Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. | lld:pubmed |
| pubmed-article:7964506 | pubmed:affiliation | Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia. | lld:pubmed |
| pubmed-article:7964506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7964506 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7964506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
