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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-12-23
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pubmed:abstractText |
Lymphoproliferation, chronic B cell activation resulting in hypergammaglobulinemia, and profound immunodeficiency are prominent features of a retrovirus-induced syndrome designated murine acquired immunodeficiency syndrome (MAIDS). In vivo treatment of infected mice with recombinant interleukin 12 (IL-12) beginning at the time of infection or up to 9 wk after virus inoculation markedly inhibited the development of splenomegaly and lymphadenopathy, as well as B cell activation and Ig secretion. Treatment with IL-12 also had major effects in preventing induction of several immune defects including impaired production of interferon gamma (IFN-gamma) and IL-2 and depressed proliferative responses to various stimuli. The therapeutic effects of IL-12 on the immune system of mice with MAIDS were also associated with reduced expression of the retrovirus that causes this disease (BM5def), with lesser effects on expression of ecotropic MuLV. IL-12 treatment was not effective in IFN-gamma knockout mice or in infected mice treated simultaneously with IL-12 and anti-IFN-gamma. These results demonstrate that induction and progression of MAIDS are antagonized by IL-12 through high-level expression of IFN-gamma and may provide an experimental basis for developing treatments of retrovirus-induced immune disorders with similar immunopathogenic mechanisms.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1345785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1346797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1350290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1351086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1351500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1357073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-14462662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1503680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1506689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1658361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1693082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1967300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-1980114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2204066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2464640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2504877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2523712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2536830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2538760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2542949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2642947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2842430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2955050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2967332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-2984305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-3035057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-6085451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-6422299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7690809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7901851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7903123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7905500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7907107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7908322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-7908324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8023146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8096238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8097322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8097338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8097524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8100999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8102101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8211142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964495-8456300
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2199-208
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7964495-Animals,
pubmed-meshheading:7964495-Antibodies, Monoclonal,
pubmed-meshheading:7964495-B-Lymphocytes,
pubmed-meshheading:7964495-Base Sequence,
pubmed-meshheading:7964495-DNA Primers,
pubmed-meshheading:7964495-Female,
pubmed-meshheading:7964495-Flow Cytometry,
pubmed-meshheading:7964495-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:7964495-Interferon-gamma,
pubmed-meshheading:7964495-Interleukin-12,
pubmed-meshheading:7964495-Lymphocyte Activation,
pubmed-meshheading:7964495-Mice,
pubmed-meshheading:7964495-Mice, Inbred C57BL,
pubmed-meshheading:7964495-Molecular Sequence Data,
pubmed-meshheading:7964495-Murine Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7964495-Organ Size,
pubmed-meshheading:7964495-Polymerase Chain Reaction,
pubmed-meshheading:7964495-Recombinant Proteins,
pubmed-meshheading:7964495-Splenomegaly,
pubmed-meshheading:7964495-Time Factors
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pubmed:year |
1994
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