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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-12-23
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pubmed:abstractText |
Susceptibility to T lymphomas in mice is determined by a number of viral and host genetic factors. We analyzed the types and latent period of lymphomas spontaneously occurring in crosses between AKR/Ms, a T lymphoma-prone mouse strain, and SL/Kh, a pre-B lymphoma-prone strain. The incidence of T lymphomas in the F1 hybrids backcross to SL/Kh as well as F2 generation mice indicated that a dominant host gene thymic lymphoma susceptible mouse-1 (Tlsm-1) of AKR/Ms determined the type of lymphomas to be thymic. Linkage analysis with microsatellite markers assigned Tlsm-1 to the map position 61 cM from centromere of the chromosome 7. Close scrutiny of this region of AKXD recombinant inbred strains for spontaneous T lymphomas revealed the presence of Tlsm-1-like gene most likely between D7MIT71 (map position 62) and D7MIT13 (map position 70). On the other hand, a SL/Kh-derived recessive allele at a major histocompatibility complex (MHC)-linked locus accelerated development of both T and B lymphomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1461647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1508213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1675432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1679753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1680807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-1847454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-197197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-204014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-2250098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-2347365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-2828679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-2926325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3039180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3115925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3259177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3692487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3856101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-3978615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-4343244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-6217253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-6244357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-6306133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-6323743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-6962782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8098217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8099513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8105477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8275475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8275476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8326739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8383230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964490-8407546
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:geneSymbol |
TLSM-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2155-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7964490-Animals,
pubmed-meshheading:7964490-Chromosome Mapping,
pubmed-meshheading:7964490-Crosses, Genetic,
pubmed-meshheading:7964490-Female,
pubmed-meshheading:7964490-Genes, Dominant,
pubmed-meshheading:7964490-Genetic Linkage,
pubmed-meshheading:7964490-Genetic Markers,
pubmed-meshheading:7964490-Genetic Predisposition to Disease,
pubmed-meshheading:7964490-Heterozygote,
pubmed-meshheading:7964490-Homozygote,
pubmed-meshheading:7964490-Lymphoma, T-Cell,
pubmed-meshheading:7964490-Male,
pubmed-meshheading:7964490-Mice,
pubmed-meshheading:7964490-Mice, Inbred AKR,
pubmed-meshheading:7964490-Mice, Inbred Strains,
pubmed-meshheading:7964490-Mice, Mutant Strains,
pubmed-meshheading:7964490-Recombination, Genetic,
pubmed-meshheading:7964490-Thymus Neoplasms
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pubmed:year |
1994
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pubmed:articleTitle |
T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
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pubmed:affiliation |
Department of Pathology, Faculty of Medicine, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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