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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1994-12-1
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pubmed:abstractText |
Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL-7R. Mutant mice display a profound reduction in thymic and peripheral lymphoid cellularity. Analyses of lymphoid progenitor populations in IL-7R-deficient mice define precisely those developmental stages affected by the mutation and reveal a critical role for IL-7R during early lymphoid development. Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1359428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1381391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1386962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1387147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1579166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1827140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1830926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-1948049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2038316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2123223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2188660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2205396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2324686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2518727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2787360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2787384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-2788467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-3194019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-3259677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-6608556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-6978185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-7678850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-7681470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8100269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8266076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8266077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8315381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8387893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8395346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8415665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8456301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7964471-8462096
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD43,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spn protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:DavisonB LBL,
pubmed-author:GliniakB CBC,
pubmed-author:GrabsteinK HKH,
pubmed-author:MaraskovskyEE,
pubmed-author:MeyerJ DJD,
pubmed-author:MorrisseyP JPJ,
pubmed-author:ParkL SLS,
pubmed-author:PeschonJ JJJ,
pubmed-author:RamsdellF JFJ,
pubmed-author:WareC BCB,
pubmed-author:WilliamsD EDE,
pubmed-author:ZieglerS FSF
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1955-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7964471-Animals,
pubmed-meshheading:7964471-Antigens, CD,
pubmed-meshheading:7964471-Antigens, CD4,
pubmed-meshheading:7964471-Antigens, CD43,
pubmed-meshheading:7964471-Antigens, CD8,
pubmed-meshheading:7964471-Female,
pubmed-meshheading:7964471-Interleukin-7,
pubmed-meshheading:7964471-Lymphocytes,
pubmed-meshheading:7964471-Male,
pubmed-meshheading:7964471-Mice,
pubmed-meshheading:7964471-Mice, Inbred C57BL,
pubmed-meshheading:7964471-Receptors, Interleukin,
pubmed-meshheading:7964471-Receptors, Interleukin-2,
pubmed-meshheading:7964471-Receptors, Interleukin-7,
pubmed-meshheading:7964471-Sialoglycoproteins
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pubmed:year |
1994
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pubmed:articleTitle |
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
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pubmed:affiliation |
Immunex Research and Development Corporation, Seattle, Washington 98101.
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pubmed:publicationType |
Journal Article
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