Linked Life Data

7962413

Source:http://linkedlifedata.com/resource/pubmed/id/7962413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-12-15
pubmed:abstractText
The factors involved in post-fertilization events leading to implantation in mammals are discussed with special reference to potential forms of interception. The stages of embryonic growth until implantation are considered initially. The growth and differentiation of the uterine endometrium is then described, followed by the events occurring during the apposition and invasion of the implanting embryo. Several potential approaches to new forms of interception are considered, and the advantages and disadvantages of each of them are evaluated. Among them, new vaccines against the zona pellucida, inactivation of the secretions of the blastocyst, hatching, the activity of pinopodes, and the endometrial proteins produced in the secretory phase seem to offer various and varied targets. Some existing methods of fertility regulation may act by affecting these stages of development, e.g. RU486 may interfere with pinopod function. Various physiological and embryonic consequences of interfering with these stages of pregnancy are discussed.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, Immunological, http://linkedlifedata.com/resource/pubmed/keyword/Contraception Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Mode Of Action, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Implantation, http://linkedlifedata.com/resource/pubmed/keyword/Implantation Suppression, http://linkedlifedata.com/resource/pubmed/keyword/Literature Review, http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy, http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy, First Trimester, http://linkedlifedata.com/resource/pubmed/keyword/Preimplantation Phase, http://linkedlifedata.com/resource/pubmed/keyword/Reproduction
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
985-95
pubmed:dateRevised
2005-11-16
pubmed:otherAbstract
PIP: This review addresses factors linked to postfertilization phenomena progressing to implantation, particularly as they apply to potential forms of interception. The targets for interception include embryonic development before implantation, tubal transport and tubal milieu, endometrial development before implantation, embryonic signalling to the mother, and embryo-uterine apposition, adhesion, and invasion. Researchers are developing vaccines against zona glycoproteins (ZP2f and ZP3f) to interfere with the preimplantation embryo. They are looking at inactivating strypsin to prevent the hatching of the blastocyst. Researchers are considering targeting the specific binding proteins or glycoproteins expressed during adhesion of the embryo to the uterus to prevent implantation. The endometrial specific proteins IGFBP-1 and alpha2-PEG are other targets for interception. They must be inactivated before implantation to prevent damage to fetal growth. Progesterone deficiency or its impairment of action do not always prevent implantation. Embryos can persist at low levels of progesterone for several days (4-5 days) after they arrive in the uterus. In fact, the embryo's own steroids can maintain a local uterine milieu until it can secrete human chorionic gonadotropin. Failures of interfering with implantation may damage some embryos, cause biochemical pregnancies or blighted ova, and result in pregnancy complications (e.g., placenta previa). Any form of interception must meet high standards of acceptability, efficiency, and safety. We need to better understand the processes of human implantation.
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Implantation, interception and contraception.
pubmed:affiliation
Churchill College, Cambridge and London Women's Clinic, UK.
pubmed:publicationType
Journal Article, Review