Linked Life Data

7962378

Source:http://linkedlifedata.com/resource/pubmed/id/7962378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-12-15
pubmed:abstractText
The potential advantages of pulsatile s.c. administration instead of daily bolus i.m. administration of human urinary gonadotrophin preparations were tested after the administration of a long-acting gonadotrophin-releasing hormone (GnRH) analogue within a programme for in-vitro fertilization (IVF) and embryo transfer. First, the pharmacokinetic properties of human urinary gonadotrophins were analysed with immunological and biological methods, both during bolus i.m. injections and during pulsatile s.c. administration. Second, a prospective randomized controlled study was performed in 75 patients undergoing IVF/embryo transfer in whom the effects of pulsatile s.c. administration were compared with the effects of single daily bolus i.m. injections of the same gonadotrophin preparation. The results showed that neither method of gonadotrophin administration induced measurable changes in the serum concentration of luteinizing hormone (LH). Both oestradiol and androstenedione concentrations were slightly lower during pulsatile s.c. gonadotrophin administration, suggesting that this method of gonadotrophin administration results in less LH occupying the ovarian LH receptors. Pulsatile s.c. gonadotrophin administration resembles a continuous infusion of follicle-stimulating hormone (FSH). Significant fluctuations in the serum concentrations of FSH were observed during single daily bolus i.m. administration of human urinary gonadotrophins, but the pregnancy rate of IVF/embryo transfer per cycle after pulsatile s.c. administration was not significantly better than after the daily bolus i.m. injection of gonadotrophins (42.1 versus 37.2%). It is concluded that pulsatile s.c. administration of gonadotrophins instead of single daily injections does not improve the pregnancy rate in IVF/embryo transfer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1070-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:7962378-Adult, pubmed-meshheading:7962378-Delayed-Action Preparations, pubmed-meshheading:7962378-Drug Administration Schedule, pubmed-meshheading:7962378-Embryo Transfer, pubmed-meshheading:7962378-Female, pubmed-meshheading:7962378-Fertilization in Vitro, pubmed-meshheading:7962378-Follicle Stimulating Hormone, pubmed-meshheading:7962378-Gonadotropins, pubmed-meshheading:7962378-Humans, pubmed-meshheading:7962378-Injections, Intramuscular, pubmed-meshheading:7962378-Injections, Subcutaneous, pubmed-meshheading:7962378-Luteinizing Hormone, pubmed-meshheading:7962378-Male, pubmed-meshheading:7962378-Middle Aged, pubmed-meshheading:7962378-Ovulation Induction, pubmed-meshheading:7962378-Pituitary Gland, pubmed-meshheading:7962378-Prospective Studies, pubmed-meshheading:7962378-Treatment Outcome, pubmed-meshheading:7962378-Triptorelin Pamoate
pubmed:year
1994
pubmed:articleTitle
Pulsatile subcutaneous versus bolus intramuscular gonadotrophin administration after pituitary suppression with a long-acting gonadotrophin-releasing hormone analogue: a controlled prospective study.
pubmed:affiliation
Department of Obstetrics and Gynaecology, Westfälische, Wilhelms University, Münster, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't