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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1994-12-21
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pubmed:abstractText |
We report the case of a patient with bilateral testicular tumors and congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Catheterization of the left testicular and adrenal veins was performed. The presence of 11 beta-hydroxylated steroids in the spermatic veins confirmed the presence of testicular tumor secondary to adrenal rest cells. After adrenal suppression by dexamethasone combined with gonadal stimulation with hCG, a dramatic decrease in androgens and adrenal steroids was observed in the peripheral blood. Compared to the periphery, 21-deoxycortisol and 11 beta-hydroxy-delta 4-androstenedione levels remained higher than that of 21-deoxycorticosterone in the gonadal vein, but not in the adrenal vein, which seems to indicate that the nature of this ectopic tissue is unusual and that its sensitivity to dexamethasone depends on the adrenocortical zones. No rise in estradiol or testosterone was obtained after hCG stimulation, suggesting that all of the testicular tissue was inactive or destroyed. This finding was confirmed by histological examination.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chorionic Gonadotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1390-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7962333-Adrenal Glands,
pubmed-meshheading:7962333-Adrenal Hyperplasia, Congenital,
pubmed-meshheading:7962333-Adult,
pubmed-meshheading:7962333-Catheterization,
pubmed-meshheading:7962333-Chorionic Gonadotropin,
pubmed-meshheading:7962333-Dexamethasone,
pubmed-meshheading:7962333-Follicle Stimulating Hormone,
pubmed-meshheading:7962333-Humans,
pubmed-meshheading:7962333-Luteinizing Hormone,
pubmed-meshheading:7962333-Male,
pubmed-meshheading:7962333-Testicular Neoplasms,
pubmed-meshheading:7962333-Testis,
pubmed-meshheading:7962333-Testosterone
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pubmed:year |
1994
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pubmed:articleTitle |
Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumors and congenital adrenal hyperplasia.
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pubmed:affiliation |
Service d'Endocrinologie, Diabétologie et Nutrition, Hôpital Jean Verdier, Bondy, France.
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pubmed:publicationType |
Journal Article,
Case Reports
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