Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-12-23
pubmed:abstractText
Mammary gland development is controlled by systemic hormones and by growth factors that might complement or mediate hormonal action. Peptides that locally signal growth cessation and stimulate differentiation of the developing epithelium have not been described. Here, we report that recombinant and wild-type forms of mammary-derived growth inhibitor (MDGI) and heart-fatty acid binding protein (FABP), which belong to the FABP family, specifically inhibit growth of normal mouse mammary epithelial cells (MEC), while growth of stromal cells is not suppressed. In mammary gland organ culture, inhibition of ductal growth is associated with the appearance of bulbous alveolar end buds and formation of fully developed lobuloalveolar structures. In parallel, MDGI stimulates its own expression and promotes milk protein synthesis. Selective inhibition of endogenous MDGI expression in MEC by antisense phosphorothioate oligonucleotides suppresses appearance of alveolar end buds and lowers the beta-casein level in organ cultures. Furthermore, MDGI suppresses the mitogenic effects of epidermal growth factor, and epidermal growth factor antagonizes the activities of MDGI. Finally, the regulatory properties of MDGI can be fully mimicked by an 11-amino acid sequence, represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs. This peptide does not bind fatty acids. To our knowledge, this is the first report about a growth inhibitor promoting mammary gland differentiation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1280424, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1327537, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-13611531, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1429365, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1527171, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1594582, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1646956, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1672087, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1720307, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1847931, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1898993, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1899225, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1918550, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1963464, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1981402, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1986376, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-1991151, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2005092, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2032784, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2083086, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2085442, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2182652, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2199796, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2266970, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2292240, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2335570, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2370872, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2371287, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2500117, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2701895, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2760043, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2806261, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2918043, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-2988925, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3034921, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3230093, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3259938, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3323813, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3365397, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3409882, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3467345, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3474783, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3493223, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3498730, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3520554, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3525127, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3667628, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-3830160, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-4016153, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-4760586, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-5217449, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6300862, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6363109, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6411703, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6538567, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6893197, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-6966378, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-7001510, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8140117, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8253379, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8312397, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8353596, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8416990, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8424121, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8424125, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8468371, http://linkedlifedata.com/resource/pubmed/commentcorrection/7962070-8491177
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/FABP3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/FABP7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Fabp3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9525
pubmed:author
More...