Linked Life Data

7961222

Source:http://linkedlifedata.com/resource/pubmed/id/7961222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-12-12
pubmed:abstractText
The effects of coronary flow on cardiac capillary permeability-surface area products and interstitial spaces were examined at rest and after hemodilution in the canine heart. Multiple-indicator-dilution experiments and left atrial injections of microspheres were carried out in closed-chest anesthetized animals at rest and after plasma expansion with dextran. Plasma expansion was utilized to produce a large increase in coronary perfusion compared with control conditions. Values for plasma flow per unit interstitial space, derived from analysis of the indicator-dilution data, were found to correlate closely with average vascular plasma flow per gram, calculated from the cardiac microsphere data; the one reflects the other. With an increase in flow, cardiac capillary permeability-surface area product values were found to increase substantially, whereas the average sucrose extravascular or cardiac interstitial spaces remained stable. Consequently the dilution parameter, flow per unit interstitial space, which is independent of tracer loss, provided a good reflection of flow per weight of tissue in the heart, without the additional requirement for a flow probe.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Microsphere and dilution measurements of flow and interstitial space in dog heart.
pubmed:affiliation
McGill University Medical Clinic, Montreal General Hospital, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't