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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1994-12-8
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pubmed:abstractText |
1. Dehydrozingeronolol (DZPN; 0.1, 0.5, 1.0 mg/kg, i.v.) produced a dose-dependent bradycardia response and a sustained pressor action in urethane-anesthetized normotensive rats. DZPN inhibited the tachycardia effects by (-)isoproterenol, but had no blocking effect on the arterial pressor responses induced by phenylephrine. 2. In in vitro study, DZPN antagonized (-)isoproterenol-induced positive chronotropic effects in guinea-pig isolated right atria and relaxation responses in rat isolated uterus horns. 3. DZPN causes mild direct cardiac depression at high concentrations without intrinsic sympathomimetic activity (ISA). 4. The order of potency of beta-adrenoceptor antagonists in competing for the [3H]dihydroalprenolol binding sites was (-)propranolol >> DZPN > or = atenolol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Butanones,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroalprenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Styrenes,
http://linkedlifedata.com/resource/pubmed/chemical/methyl-3-methoxy-4-hydroxystyryl...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7958725-Adrenergic beta-Antagonists,
pubmed-meshheading:7958725-Animals,
pubmed-meshheading:7958725-Blood Pressure,
pubmed-meshheading:7958725-Butanones,
pubmed-meshheading:7958725-Dihydroalprenolol,
pubmed-meshheading:7958725-Female,
pubmed-meshheading:7958725-Guinea Pigs,
pubmed-meshheading:7958725-Heart Rate,
pubmed-meshheading:7958725-Male,
pubmed-meshheading:7958725-Propanolamines,
pubmed-meshheading:7958725-Rats,
pubmed-meshheading:7958725-Rats, Wistar,
pubmed-meshheading:7958725-Receptors, Adrenergic, beta-1,
pubmed-meshheading:7958725-Receptors, Adrenergic, beta-2,
pubmed-meshheading:7958725-Styrenes
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pubmed:year |
1994
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pubmed:articleTitle |
A new beta-adrenoceptor blocking agent derived from dehydrozingerone.
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pubmed:affiliation |
Department of Pharmacology, Kaohsiung Medical College, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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