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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1994-11-30
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pubmed:abstractText |
Bistramide A, a new toxin isolated from the Urochordate Lissoclinum bistratum Sluiter, was applied to rat auricular heart muscle bundles. At a stimulation frequency of 0.2 Hz, the toxin induces a dose-dependent reduction of the stimulated twitch tension force; it decreases Vmax and shortens the duration of the plateau and the slow repolarizing phase of the action potential. In the control solution, switching from a stimulation frequency of 0.2 Hz to 1 Hz decreases the force with which a positive potentiation develops either at a maintained high frequency or after switching from 1 Hz to 0.2 Hz. Bistramide A reduces both the force evoked at 1 Hz and the potentiation. The data suggest that Bistramide A blocks Na+ conductance; inhibits Ca++ channels in a time- and frequency-dependent manner; reduces Na(+)-Ca++ exchange activity; but does not modify the ability of the sarcoplasmic reticulum to be refilled although the rate of Ca++ accumulation is decreased.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-4754
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
926-30
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7957766-Acetamides,
pubmed-meshheading:7957766-Action Potentials,
pubmed-meshheading:7957766-Animals,
pubmed-meshheading:7957766-Atrial Function,
pubmed-meshheading:7957766-Calcium,
pubmed-meshheading:7957766-Calcium Channel Blockers,
pubmed-meshheading:7957766-Calcium Channels,
pubmed-meshheading:7957766-Depression, Chemical,
pubmed-meshheading:7957766-Electric Conductivity,
pubmed-meshheading:7957766-Ethers, Cyclic,
pubmed-meshheading:7957766-Heart Atria,
pubmed-meshheading:7957766-Kinetics,
pubmed-meshheading:7957766-Male,
pubmed-meshheading:7957766-Myocardial Contraction,
pubmed-meshheading:7957766-Pyrans,
pubmed-meshheading:7957766-Rats,
pubmed-meshheading:7957766-Rats, Wistar,
pubmed-meshheading:7957766-Sodium,
pubmed-meshheading:7957766-Spiro Compounds
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pubmed:year |
1994
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pubmed:articleTitle |
Influence of Bistramide A on the twitch tension in rat atrial heart muscle.
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pubmed:affiliation |
Laboratoire de Physiologie Cellulaire, ERS CNRS F0100, Université de Paris XI, Orsay, France.
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pubmed:publicationType |
Journal Article
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