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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
1
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pubmed:dateCreated |
1994-12-2
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|
pubmed:abstractText |
Interferons (IFNs) are cytokines that exert an antiviral effect on target cells and possess immunomodulatory and antitumor properties. In this study we have investigated the effects of human recombinant IFN-gamma on human leukemic B cell lines at different stages of maturation. Our data show that in Burkitt's lymphoma RAMOS-1 B cells IFN-gamma induces a reduction of cell growth and a clonal selection via programmed cell death; in contrast, IFN-gamma treatment of KM-3 pre-B cells does not induce biochemical and morphological changes as shown by electron microscope analysis and DNA gel electrophoresis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-4827
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
215
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
23-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7957674-Apoptosis,
pubmed-meshheading:7957674-Burkitt Lymphoma,
pubmed-meshheading:7957674-Cell Differentiation,
pubmed-meshheading:7957674-Cell Division,
pubmed-meshheading:7957674-Cell Line,
pubmed-meshheading:7957674-DNA, Neoplasm,
pubmed-meshheading:7957674-DNA Nucleotidylexotransferase,
pubmed-meshheading:7957674-Flow Cytometry,
pubmed-meshheading:7957674-Humans,
pubmed-meshheading:7957674-Immunohistochemistry,
pubmed-meshheading:7957674-Interferon-gamma,
pubmed-meshheading:7957674-Leukemia, B-Cell,
pubmed-meshheading:7957674-Microscopy, Electron,
pubmed-meshheading:7957674-Recombinant Proteins,
pubmed-meshheading:7957674-Thymidine,
pubmed-meshheading:7957674-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Interferon-gamma (IFN-gamma) induces programmed cell death in differentiated human leukemic B cell lines.
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pubmed:affiliation |
Istituto di Citomorfologia Normale e Patologica del CNR, Università di Chieti, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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