Linked Life Data

79567

Source:http://linkedlifedata.com/resource/pubmed/id/79567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1978-10-18
pubmed:abstractText
Treatment of hepatitis B surface antigen (HBsAg) with either chloroform-methanol (2:1, v/v) or 50% 1,1',3,3'-tetramethylurea did not affect the morphological integrity of the particles (about 20 nm in diameter), although the major portion of lipids was released as indicated by their increased buoyant density in CsCl (1.27 g/cm3 as compared with 1.20 g/cm3 for intact HBsAg). The antigenicity and polypeptide composition of HBsAg was not altered by delipidation. The carbohydrate chains of HBsAg contain penultimate beta-D-galactosyl residues. HBsAg was cleaved by chymotrypsin into fragments which were smaller than intact HBsAg by two orders of magnitude and which contained both the a and d determinants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5526
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Properties of delipidated hepatitis B surface antigen (HBsAg) and preparation of its proteolytic cleavage fragments carrying HBsAg-specific antigenic determinants.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.