| pubmed-article:7955823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7955823 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:7955823 | lifeskim:mentions | umls-concept:C0332170 | lld:lifeskim |
| pubmed-article:7955823 | lifeskim:mentions | umls-concept:C0587117 | lld:lifeskim |
| pubmed-article:7955823 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7955823 | pubmed:dateCreated | 1994-12-20 | lld:pubmed |
| pubmed-article:7955823 | pubmed:abstractText | Quinolone antimicrobials absorb ultraviolet radiation and, with appropriate drug concentrations, may cause photoreactions. Photoreactions have been reported for several quinolones, including lomefloxacin, a difluorinated quinolone antimicrobial. This study was designed to determine whether the interval between administration of lomefloxacin and exposure to ultraviolet A (UVA) light would affect skin responses. The minimal erythema dose (MED) and severity of local reactions were the main parameters of evaluation. Exposure to UVA radiation 2 hours after morning dosing caused an increase in skin sensitivity as assessed by changes in MED (p < 0.05). No changes were observed with exposure 16 hours after evening dosing (p = 1.00). Edema and blisters at the radiation sites were observed in only the morning dosing group. A significant negative correlation was observed between lomefloxacin plasma concentrations and change MEDs (r = -0.72; p < 0.05). An evening dosing strategy may minimize the risk of phototoxic effects. | lld:pubmed |
| pubmed-article:7955823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7955823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955823 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7955823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7955823 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7955823 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:LoweN JNJ | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:SternR SRS | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:BourgetTT | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:FakouhiT DTD | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:SwabbE AEA | lld:pubmed |
| pubmed-article:7955823 | pubmed:author | pubmed-author:RonikerBB | lld:pubmed |
| pubmed-article:7955823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7955823 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:7955823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7955823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7955823 | pubmed:pagination | 587-91 | lld:pubmed |
| pubmed-article:7955823 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:meshHeading | pubmed-meshheading:7955823-... | lld:pubmed |
| pubmed-article:7955823 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7955823 | pubmed:articleTitle | Photoreactions with a fluoroquinolone antimicrobial: evening versus morning dosing. | lld:pubmed |
| pubmed-article:7955823 | pubmed:affiliation | Skin Research Foundation, Santa Monica. | lld:pubmed |
| pubmed-article:7955823 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7955823 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7955823 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:7955823 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7955823 | lld:pubmed |
