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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1994-11-25
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pubmed:abstractText |
Earlier studies have established that the rodent bladder carcinogen o-anisidine (OA) gives negative results in all of the standard rodent genetic toxicity assays. In the present study, a single oral administration of the maximum tolerated dose level (750 mg/kg) of OA to B6C3F1 mice yielded negative results in 32P-post-labelling assays of bladder and liver DNA (24 h after dosing). Likewise, 14C-ring-labelled OA administered orally to B6C3F1 mice gave no evidence of DNA binding 6, 12 or 24 h later. Administration of OA (750 mg/kg) to transgenic lacI- mice (Big Blue) led to a small increase in mutation frequency (MF) in the bladder, but not in the liver. Increased MFs were observed in the bladder following 1, 3 or 10 daily doses with sampling times of 1 or 2 weeks after the final dose. However, statistical significance (P < 0.01) was only reached 2 weeks after either 3 or 10 daily administrations of OA. The positive control chemical (dimethylnitrosamine) gave a positive result (P < 0.01) in the liver, but not the bladder, 7 days after a single administration of 10 mg/kg. The possibility that OA is mutagenic and carcinogenic to the rodent bladder via formation of radical species is suggested.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-anisidine,
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus Radioisotopes
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0143-3334
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
2291-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7955069-Aniline Compounds,
pubmed-meshheading:7955069-Animals,
pubmed-meshheading:7955069-Carbon Radioisotopes,
pubmed-meshheading:7955069-Carcinogens,
pubmed-meshheading:7955069-DNA,
pubmed-meshheading:7955069-DNA Adducts,
pubmed-meshheading:7955069-Dose-Response Relationship, Drug,
pubmed-meshheading:7955069-Female,
pubmed-meshheading:7955069-Liver,
pubmed-meshheading:7955069-Mice,
pubmed-meshheading:7955069-Mice, Transgenic,
pubmed-meshheading:7955069-Mutagenicity Tests,
pubmed-meshheading:7955069-Mutation,
pubmed-meshheading:7955069-Phosphorus Radioisotopes,
pubmed-meshheading:7955069-Urinary Bladder
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pubmed:year |
1994
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pubmed:articleTitle |
Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.
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pubmed:affiliation |
Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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