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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-12-20
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pubmed:databankReference |
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pubmed:abstractText |
dpy-27 is an essential dosage compensation gene that acts to reduce expression of both hermaphrodite X chromosomes. The DPY-27 protein becomes specifically localized to the X chromosomes of wild-type XX embryos, but remains diffusely distributed throughout the nuclei of male (XO) embryos. In xol-1 mutant XO embryos that activate the XX mode of dosage compensation and die from inappropriately low X chromosome transcript levels, DPY-27 becomes localized to X. Therefore, sex specificity of the dosage compensation process is regulated at the step of DPY-27 X chromosome localization. DPY-27 exhibits striking similarity to proteins required for assembly and structural maintenance of Xenopus chromosomes in vitro and for segregation of yeast chromosomes in vivo. These findings suggest a link between global regulation of gene expression and higher order chromosome structure. We propose that DPY-27 implements dosage compensation by condensing the chromatin structure of X in a manner that causes general reduction of X chromosome expression.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NCAPH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCAP-C protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/structural maintenance of...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
79
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pubmed:geneSymbol |
dpy-27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-74
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7954812-Amino Acid Sequence,
pubmed-meshheading:7954812-Animals,
pubmed-meshheading:7954812-Caenorhabditis elegans,
pubmed-meshheading:7954812-Caenorhabditis elegans Proteins,
pubmed-meshheading:7954812-Carrier Proteins,
pubmed-meshheading:7954812-Cell Cycle Proteins,
pubmed-meshheading:7954812-Chromatin,
pubmed-meshheading:7954812-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:7954812-Chromosome Mapping,
pubmed-meshheading:7954812-Disorders of Sex Development,
pubmed-meshheading:7954812-Dosage Compensation, Genetic,
pubmed-meshheading:7954812-Female,
pubmed-meshheading:7954812-Fluorescent Antibody Technique,
pubmed-meshheading:7954812-Fungal Proteins,
pubmed-meshheading:7954812-Gene Expression Regulation,
pubmed-meshheading:7954812-In Situ Hybridization,
pubmed-meshheading:7954812-Larva,
pubmed-meshheading:7954812-Male,
pubmed-meshheading:7954812-Molecular Sequence Data,
pubmed-meshheading:7954812-Nuclear Proteins,
pubmed-meshheading:7954812-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7954812-Protein Binding,
pubmed-meshheading:7954812-RNA, Messenger,
pubmed-meshheading:7954812-Recombinant Proteins,
pubmed-meshheading:7954812-Restriction Mapping,
pubmed-meshheading:7954812-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:7954812-Sequence Homology, Amino Acid,
pubmed-meshheading:7954812-Sex Differentiation,
pubmed-meshheading:7954812-Time Factors,
pubmed-meshheading:7954812-Tissue Distribution,
pubmed-meshheading:7954812-Transformation, Genetic,
pubmed-meshheading:7954812-X Chromosome,
pubmed-meshheading:7954812-Xenopus Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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