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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-11-25
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pubmed:abstractText |
1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances. 2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10. 3. Pituitary cell corticotropin production was enhanced by IL-10 treatment. 4. IL-10 induced the production of ACTH in mouse splenocytes. 5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical nucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0272-4340
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-69
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7954660-Adrenocorticotropic Hormone,
pubmed-meshheading:7954660-Animals,
pubmed-meshheading:7954660-Base Sequence,
pubmed-meshheading:7954660-Cell Line,
pubmed-meshheading:7954660-DNA, Complementary,
pubmed-meshheading:7954660-DNA Primers,
pubmed-meshheading:7954660-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7954660-Interleukin-10,
pubmed-meshheading:7954660-Mice,
pubmed-meshheading:7954660-Mice, Inbred C57BL,
pubmed-meshheading:7954660-Molecular Sequence Data,
pubmed-meshheading:7954660-Pituitary Gland,
pubmed-meshheading:7954660-Pituitary Neoplasms,
pubmed-meshheading:7954660-Polymerase Chain Reaction,
pubmed-meshheading:7954660-RNA, Neoplasm,
pubmed-meshheading:7954660-Recombinant Proteins,
pubmed-meshheading:7954660-Spleen,
pubmed-meshheading:7954660-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Evidence for the production and action of interleukin-10 in pituitary cells.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77550.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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