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7953537
Source:
http://linkedlifedata.com/resource/pubmed/id/7953537
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0682458
pubmed:issue
7
pubmed:dateCreated
1994-12-2
pubmed:abstractText
The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107782
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4
,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef
,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...
,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-9822
pubmed:author
pubmed-author:LittmanD RDR
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
4
pubmed:geneSymbol
lck
,
nef
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
618-20
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7953537-Animals
,
pubmed-meshheading:7953537-Antigens, CD4
,
pubmed-meshheading:7953537-CD4-Positive T-Lymphocytes
,
pubmed-meshheading:7953537-Cells, Cultured
,
pubmed-meshheading:7953537-Down-Regulation
,
pubmed-meshheading:7953537-Gene Products, nef
,
pubmed-meshheading:7953537-Genes, nef
,
pubmed-meshheading:7953537-HIV
,
pubmed-meshheading:7953537-Haplorhini
,
pubmed-meshheading:7953537-Humans
,
pubmed-meshheading:7953537-Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
,
pubmed-meshheading:7953537-Mice
,
pubmed-meshheading:7953537-Mice, SCID
,
pubmed-meshheading:7953537-Mice, Transgenic
,
pubmed-meshheading:7953537-Proto-Oncogene Proteins
,
pubmed-meshheading:7953537-Simian immunodeficiency virus
,
pubmed-meshheading:7953537-Virus Replication
,
pubmed-meshheading:7953537-nef Gene Products, Human Immunodeficiency Virus
pubmed:year
1994
pubmed:articleTitle
Immunodeficiency viruses. Not enough sans Nef.
pubmed:affiliation
Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143-0414.
pubmed:publicationType
Journal Article
,
Review