Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-12-29
|
| pubmed:databankReference | |
| pubmed:abstractText |
Among a number of genes that escape X-chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X-inactivation. We report here the cloning and expression studies of a novel mouse gene, Xe169, and show that it escapes X-inactivation like its human homologue. Xe169 was assigned to band F2/F3 on the mouse X chromosome by fluorescent in situ hybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome. In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes. Xe169 is the first cloned non-pseudoautosomal gene that escapes X-inactivation in mice.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1061-4036
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
Xe169
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
491-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7951318-Animals,
pubmed-meshheading:7951318-Base Sequence,
pubmed-meshheading:7951318-Chromosome Mapping,
pubmed-meshheading:7951318-Cloning, Molecular,
pubmed-meshheading:7951318-Cricetinae,
pubmed-meshheading:7951318-DNA, Complementary,
pubmed-meshheading:7951318-DNA Primers,
pubmed-meshheading:7951318-Dosage Compensation, Genetic,
pubmed-meshheading:7951318-Female,
pubmed-meshheading:7951318-Humans,
pubmed-meshheading:7951318-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7951318-Mice,
pubmed-meshheading:7951318-Mice, Inbred C57BL,
pubmed-meshheading:7951318-Molecular Sequence Data,
pubmed-meshheading:7951318-Muridae,
pubmed-meshheading:7951318-Sequence Homology, Nucleic Acid,
pubmed-meshheading:7951318-Species Specificity,
pubmed-meshheading:7951318-X Chromosome
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
The murine Xe169 gene escapes X-inactivation like its human homologue.
|
| pubmed:affiliation |
Department of Pediatrics, University of California, San Francisco 94143.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|