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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-12-12
|
| pubmed:abstractText |
The effects of gomisin A, a lignan compound of Schizandra fruits, on hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) in rats were investigated. Gomisin A inhibited both increases of the number and size of glutathione S-transferase placental form (GST-P)-positive foci, a marker enzyme of preneoplasm, and the population of diploid nuclei, as a proliferative state of hepatocytes, in the liver from rats simultaneously treated with 3'-MeDAB. Gomisin A increased GST activity in the liver, by raising the level of GST 1 and 2 isozymes. 3'-MeDAB increased GST activity and GST-P expression. This high level of GST-P induced by 3'-MeDAB was suppressed by additional treatment with gomisin A. In an experiment on simultaneous treatment, gomisin A increased the biliary excretion of 3'-MeDAB-related aminoazo dyes and decreased the content in the liver of rats fed with 0.06%-3'-MeDAB containing diet. In an experiment on pretreatment with 3'-MeDAB, even though no aminoazo dye was detectable in the liver or bile 2-weeks after cessation of 3'-MeDAB-feeding, gomisin A showed a tendency to reduce the preneoplastic changes of increases in GST-P positive foci and diploid nuclei in the liver. These results suggest that gomisin A inhibits the hepatocarcinogenesis induced by 3'-MeDAB by enhancing the excretion of the carcinogen from the liver and by reversing the normal cytokinesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooctanes,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxoles,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lignans,
http://linkedlifedata.com/resource/pubmed/chemical/Methyldimethylaminoazobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/schizandrol B
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0918-6158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
808-14
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7951143-Animals,
pubmed-meshheading:7951143-Cell Division,
pubmed-meshheading:7951143-Cell Nucleus,
pubmed-meshheading:7951143-Cyclooctanes,
pubmed-meshheading:7951143-Diet,
pubmed-meshheading:7951143-Dioxoles,
pubmed-meshheading:7951143-Drugs, Chinese Herbal,
pubmed-meshheading:7951143-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7951143-Flow Cytometry,
pubmed-meshheading:7951143-Glutathione Transferase,
pubmed-meshheading:7951143-Immunoblotting,
pubmed-meshheading:7951143-Immunohistochemistry,
pubmed-meshheading:7951143-Isoenzymes,
pubmed-meshheading:7951143-Lignans,
pubmed-meshheading:7951143-Liver,
pubmed-meshheading:7951143-Liver Neoplasms,
pubmed-meshheading:7951143-Male,
pubmed-meshheading:7951143-Methyldimethylaminoazobenzene,
pubmed-meshheading:7951143-Ploidies,
pubmed-meshheading:7951143-Protein Binding,
pubmed-meshheading:7951143-Rats
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats.
|
| pubmed:affiliation |
Research Laboratory for Development of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
|
| pubmed:publicationType |
Journal Article
|