Linked Life Data

7950775

Source:http://linkedlifedata.com/resource/pubmed/id/7950775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-12-6
pubmed:abstractText
The effects of endothelin (0.1 nMol/kg and 1 nMol/kg into the left ventricle) on hemodynamics and cardiac contractility were investigated in conscious and unrestrained, WKY rats before and during continuous infusion of atriopeptides (1 microgram/kg/min i.v.). Bolus injection on endothelin into the left ventricle caused a transient hypotension and tachycardia followed by a long-lasting increase in mean blood pressure (MBP) and bradycardia in intact rats. In the rats receiving constant atriopeptide infusions, the hypotensive phase of endothelin effects was augmented whereas the hypertensive phase was reduced. Endothelin doses dependently increased cardiac contractility parameters during the first 3 minutes after injection. The stimulation of cardiac function at this time resulted from reflex responses due to the rapid decrease in the MBP. These effects were followed by decreases in cardiac contractility indices. Infusion of atriopeptide led to a tendency to the positive inotropic action of and augmented the negative inotropic action of endothelin.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0869-2092
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
[The effect of endothelin on the hemodynamics and cardiac contractility in waking rats with normal and artificially elevated levels of atriopeptide in the blood].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract