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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1994-12-7
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pubmed:abstractText |
We have designed an automated system for controlled exposure of rodents to nitrogen dioxide (NO2). The system consists of 1) two stainless-steel exposure chambers (3.96 m3), for control and treated animals, in which temperature, humidity, and air changes are consistent with current guidelines for rodent housing; 2) a cylinder containing 1% NO2 in N2; 3) a detector connected with a personal computer system that monitors the NO2 concentration, and regulates the NO2 influx, using a closed-loop feedback; and 4) a fan system to distribute the gas uniformly within the chambers. In a typical experiment rats were exposed to 15 ppm of NO2, and changes in the differential count of polymorphonuclear leukocytes, macrophages, and lymphocytes in bronchoalveolar lavage fluid were investigated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1056-8719
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7949374-Animals,
pubmed-meshheading:7949374-Atmosphere Exposure Chambers,
pubmed-meshheading:7949374-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:7949374-Lung,
pubmed-meshheading:7949374-Lymphocytes,
pubmed-meshheading:7949374-Macrophages,
pubmed-meshheading:7949374-Male,
pubmed-meshheading:7949374-Neutrophils,
pubmed-meshheading:7949374-Nitrogen Dioxide,
pubmed-meshheading:7949374-Rats
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pubmed:year |
1994
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pubmed:articleTitle |
An automated system for animal exposure to nitrogen dioxide.
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pubmed:affiliation |
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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