|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1994-12-20
|
|
pubmed:abstractText |
Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synthesis and mitosis accompanied by a marked increase in expression of an array of cell surface activation antigens. The resultant activated B-CLL cells exhibit greatly enhanced sensitivity to cycle-active cytotoxic drugs. This approach may be of potential value in the therapy of CLL.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0006-4971
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
84
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3457-64
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7949100-Adult,
pubmed-meshheading:7949100-Aged,
pubmed-meshheading:7949100-Antibodies, Monoclonal,
pubmed-meshheading:7949100-Antigens, CD,
pubmed-meshheading:7949100-Antineoplastic Agents,
pubmed-meshheading:7949100-Cell Cycle,
pubmed-meshheading:7949100-Cells, Cultured,
pubmed-meshheading:7949100-Dose-Response Relationship, Drug,
pubmed-meshheading:7949100-Female,
pubmed-meshheading:7949100-Guanosine,
pubmed-meshheading:7949100-Humans,
pubmed-meshheading:7949100-Immunophenotyping,
pubmed-meshheading:7949100-Leukemia, Hairy Cell,
pubmed-meshheading:7949100-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:7949100-Lymphocyte Activation,
pubmed-meshheading:7949100-Lymphocytes,
pubmed-meshheading:7949100-Male,
pubmed-meshheading:7949100-Middle Aged,
pubmed-meshheading:7949100-Mitosis
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle.
|
|
pubmed:affiliation |
Department of Immunology, Scripps Research Institute, La Jolla, CA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
