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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-12-2
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pubmed:abstractText |
HTLV-I-transformed human T-cell line, MT-2, has been reported to successfully proliferate in only the SCID mice with depletion of NK cell function. However, MT-2 cells could be engrafted into SCID mice possessing normal NK cell function in this study. MT-2 cells (5-7 x 10(7) cells) were intraperitoneally injected into SCID mice without the deletion of NK cell function. The SCID mice developed tumors in the peritoneal cavities 3 months after the inoculation of MT-2 cells. All tumors reacted to anti-HTLV-I p19 and anti-HLA-DR monoclonal antibodies by immunofluorescence assay and were also positive for the HTLV-I gene by PCR assay. DNA obtained from main organs in group of mice with or without tumors showed a high incidence of positive signals for HTLV-I gene by PCR assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0916-7250
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
601-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7948404-Animals,
pubmed-meshheading:7948404-Base Sequence,
pubmed-meshheading:7948404-Cell Line, Transformed,
pubmed-meshheading:7948404-Cell Transformation, Neoplastic,
pubmed-meshheading:7948404-DNA, Viral,
pubmed-meshheading:7948404-DNA Primers,
pubmed-meshheading:7948404-Female,
pubmed-meshheading:7948404-Fluorescent Antibody Technique,
pubmed-meshheading:7948404-Human T-lymphotropic virus 1,
pubmed-meshheading:7948404-Humans,
pubmed-meshheading:7948404-Kidney,
pubmed-meshheading:7948404-Killer Cells, Natural,
pubmed-meshheading:7948404-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:7948404-Liver,
pubmed-meshheading:7948404-Lung,
pubmed-meshheading:7948404-Lymph Nodes,
pubmed-meshheading:7948404-Lymphocyte Transfusion,
pubmed-meshheading:7948404-Male,
pubmed-meshheading:7948404-Mice,
pubmed-meshheading:7948404-Mice, SCID,
pubmed-meshheading:7948404-Molecular Sequence Data,
pubmed-meshheading:7948404-Polymerase Chain Reaction,
pubmed-meshheading:7948404-Spleen,
pubmed-meshheading:7948404-T-Lymphocytes,
pubmed-meshheading:7948404-Transplantation, Heterologous
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pubmed:year |
1994
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|
pubmed:articleTitle |
Engraftment of HTLV-I-transformed human T-cell line into SCID mice with NK cell function.
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pubmed:affiliation |
Department of Virology, Kurume University School of Medicine, Osaka University Medical School, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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