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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1994-12-6
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pubmed:abstractText |
We observed that peripheral T cells activated in vivo or in vitro by superantigens are susceptible to cell death when their antigen receptor is cross-linked with the appropriate anti-alpha beta TCR mAb. TCR ligation by mAbs specifically drove the T cell clonal deletion in both CD4+ and CD8+ cell subsets. An IL-2/IL-2R interaction seems to be a critical step in predisposing superantigen activated cells to death; in fact, in vivo IL-2R blockade reversed T cell deletion in superantigen plus anti-alpha beta TCR mAb treated mice. TCR ligation by mAbs also produced cell death of the relevant targets in in vitro IL-2 activated T cells. Surprisingly, no T cell deletion was demonstrable in IL-2 activated cells following staphylococcal enterotoxin B--TCR interaction, ruling out the possibility that superantigen in itself can induce cell death. Thus, while superantigen activation opens the cell death program, a subsequent TCR--antigen (self) interaction appears necessary to produce clonal deletion in mature T lymphocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
983-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7947466-Animals,
pubmed-meshheading:7947466-Antibodies, Monoclonal,
pubmed-meshheading:7947466-Cell Death,
pubmed-meshheading:7947466-Cells, Cultured,
pubmed-meshheading:7947466-Clonal Deletion,
pubmed-meshheading:7947466-Enterotoxins,
pubmed-meshheading:7947466-Female,
pubmed-meshheading:7947466-Flow Cytometry,
pubmed-meshheading:7947466-Interleukin-2,
pubmed-meshheading:7947466-Lymph Nodes,
pubmed-meshheading:7947466-Lymphocyte Activation,
pubmed-meshheading:7947466-Male,
pubmed-meshheading:7947466-Mice,
pubmed-meshheading:7947466-Mice, Inbred BALB C,
pubmed-meshheading:7947466-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7947466-Staphylococcus aureus,
pubmed-meshheading:7947466-Superantigens,
pubmed-meshheading:7947466-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Mechanism underlying superantigen-induced clonal deletion of mature T lymphocytes.
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pubmed:affiliation |
Institute of Experimental Pathology, Ancona, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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