Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-12-27
|
| pubmed:abstractText |
Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. This increase develops gradually over several days and remains at 50% of maximal levels 7 days after the last cocaine exposure. Supershift experiments, along with one- and two-dimensional Western blots, indicate that this chronic AP-1 complex contains at least four Fos-related antigens (FRAs), some of which display delta FosB-like immunoreactivity, that are induced selectively by chronic, but not acute, cocaine treatment. The same chronic FRAs were also induced by several different types of chronic treatments in a region-specific manner in the brain. Thus, the chronic FRAs and associated chronic AP-1 complex could mediate some of the long-term changes in gene expression unique to the chronic-treated state as opposed to the acute-treated and normal states.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0896-6273
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1235-44
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7946359-Animals,
pubmed-meshheading:7946359-Blotting, Western,
pubmed-meshheading:7946359-Brain,
pubmed-meshheading:7946359-Brain Mapping,
pubmed-meshheading:7946359-Cocaine,
pubmed-meshheading:7946359-Drug Administration Schedule,
pubmed-meshheading:7946359-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:7946359-Electroshock,
pubmed-meshheading:7946359-Isoelectric Point,
pubmed-meshheading:7946359-Male,
pubmed-meshheading:7946359-Molecular Weight,
pubmed-meshheading:7946359-Nucleus Accumbens,
pubmed-meshheading:7946359-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:7946359-Rats,
pubmed-meshheading:7946359-Rats, Sprague-Dawley,
pubmed-meshheading:7946359-Seizures,
pubmed-meshheading:7946359-Substance-Related Disorders,
pubmed-meshheading:7946359-Transcription Factor AP-1,
pubmed-meshheading:7946359-Tranylcypromine
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.
|
| pubmed:affiliation |
Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|