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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9-10
|
| pubmed:dateCreated |
1994-12-28
|
| pubmed:abstractText |
Immunomodulation of cell-mediated immunity was studied in mice treated with either lithium chloride (LiCl), anti-CD8 monoclonal antibody or their combination. While 6-day LiCl treatment decreased the ability of their splenocytes to induce a local graft-versus-host reaction--anti-CD8 abolished this effect. The proliferative response of spleen cells from those three groups of mice to concanavalin A stimulation in vitro was significantly increased. The natural killer (NK) cell toxicity of the mice was decreased by over 43% after the 6-day LiCl treatment, but was x 2.5 higher then the control value after a longer 21-d treatment. These results indicate that the immunomodulatory capacity of lithium is dependent on the type of cell population studied, and on the schedule of administration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0939-5075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
679-83
|
| pubmed:dateRevised |
2009-11-4
|
| pubmed:meshHeading |
pubmed-meshheading:7945679-Animals,
pubmed-meshheading:7945679-Antibodies, Monoclonal,
pubmed-meshheading:7945679-Antigens, CD8,
pubmed-meshheading:7945679-Crosses, Genetic,
pubmed-meshheading:7945679-Cytotoxicity, Immunologic,
pubmed-meshheading:7945679-Graft vs Host Reaction,
pubmed-meshheading:7945679-Immunity, Cellular,
pubmed-meshheading:7945679-Killer Cells, Natural,
pubmed-meshheading:7945679-Lithium Chloride,
pubmed-meshheading:7945679-Lymphocyte Activation,
pubmed-meshheading:7945679-Lymphoma,
pubmed-meshheading:7945679-Mice,
pubmed-meshheading:7945679-Mice, Inbred C57BL,
pubmed-meshheading:7945679-Mice, Inbred CBA,
pubmed-meshheading:7945679-Species Specificity,
pubmed-meshheading:7945679-Spleen,
pubmed-meshheading:7945679-T-Lymphocytes,
pubmed-meshheading:7945679-Tumor Cells, Cultured
|
| pubmed:articleTitle |
Modulation of cell-mediated immunity by lithium chloride.
|
| pubmed:affiliation |
Department of Immunology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|