| pubmed-article:7945311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0003762 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C1518332 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:7945311 | lifeskim:mentions | umls-concept:C0442821 | lld:lifeskim |
| pubmed-article:7945311 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7945311 | pubmed:dateCreated | 1994-10-31 | lld:pubmed |
| pubmed-article:7945311 | pubmed:abstractText | N omega-Hydroxy-L-arginine (L-NOHA) is a potent inhibitor of the hydrolysis of L-arginine (L-Arg) to L-ornithine (L-Orn) catalyzed by purified bovine liver arginase (BLA). It appears as one of the most powerful arginase inhibitors reported so far (Ki = 150 microM). The other products of NO synthase are either without effect (NO2-, NO3-) or much weaker inhibitors (L-citrulline (L-Cit) and NO) of BLA. Products derived from a possible hydrolysis of L-Arg (L-Orn and urea) or of L-NOHA (L-Cit, hydroxyurea and hydroxylamine) are also inactive toward BLA at concentrations up to 2 mM. The configuration of L-NOHA is important as D-NOHA is much less active, and its free -COOH and alpha-NH2 functions are required for recognition of BLA. L-NOHA is also a potent inhibitor of the arginase activity of rat liver homogenates and of murine macrophages (IC50 of 150 and 450 microM, respectively). These remarkable properties of L-NOHA could play a role in the modulation of the biosynthesis of the biological mediator NO by increasing local L-Arg concentrations. | lld:pubmed |
| pubmed-article:7945311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7945311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7945311 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7945311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7945311 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7945311 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:MansuyDD | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:LepoivreMM | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:TenuJ PJP | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:DelaforgeMM | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:YapoAA | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:BoucherJ LJL | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:VadonSS | lld:pubmed |
| pubmed-article:7945311 | pubmed:author | pubmed-author:CustotJJ | lld:pubmed |
| pubmed-article:7945311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7945311 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:7945311 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:7945311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7945311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7945311 | pubmed:pagination | 1614-21 | lld:pubmed |
| pubmed-article:7945311 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7945311 | pubmed:meshHeading | pubmed-meshheading:7945311-... | lld:pubmed |
| pubmed-article:7945311 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7945311 | pubmed:articleTitle | N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. | lld:pubmed |
| pubmed-article:7945311 | pubmed:affiliation | Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris V, CNRS URA 400, France. | lld:pubmed |
| pubmed-article:7945311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7945311 | pubmed:publicationType | Comparative Study | lld:pubmed |
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