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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1994-11-9
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pubmed:databankReference |
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pubmed:abstractText |
We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA lambda SM-1400 extends the sequence of peroxisomal CAT, whereas cDNA lambda SM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-1276175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-1461285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-1932127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-1961759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-1988962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2077689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2314278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2351134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2363689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2645293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2654139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-2657736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-3405240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-4702872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-6404901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-6841345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-7092224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7945262-984845
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
303 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7945262-Alternative Splicing,
pubmed-meshheading:7945262-Amino Acid Sequence,
pubmed-meshheading:7945262-Base Sequence,
pubmed-meshheading:7945262-Carnitine O-Acetyltransferase,
pubmed-meshheading:7945262-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:7945262-DNA, Complementary,
pubmed-meshheading:7945262-DNA Primers,
pubmed-meshheading:7945262-Gene Library,
pubmed-meshheading:7945262-Humans,
pubmed-meshheading:7945262-Introns,
pubmed-meshheading:7945262-Isoenzymes,
pubmed-meshheading:7945262-Mitochondria, Muscle,
pubmed-meshheading:7945262-Molecular Sequence Data,
pubmed-meshheading:7945262-Muscles,
pubmed-meshheading:7945262-Polymerase Chain Reaction,
pubmed-meshheading:7945262-Protein Biosynthesis,
pubmed-meshheading:7945262-Protein Sorting Signals,
pubmed-meshheading:7945262-Subcellular Fractions,
pubmed-meshheading:7945262-Transcription, Genetic
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pubmed:year |
1994
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pubmed:articleTitle |
Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.
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pubmed:affiliation |
Istituto Nazionale Neurologico C. Besta, Divisione di Biochimica e Genetica, Milano, Italia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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