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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1994-10-24
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|
pubmed:abstractText |
To assess natural immunity against the circumsporozoite (CS) protein and the synthetic vaccine SPf66, immunologic studies were carried out in a highly endemic malarious area of Papua New Guinea. Antibody prevalence, antibody titers, and T cell proliferation against both antigens were measured in 214 adults. Immunologic data were analyzed with respect to longitudinal malariologic and morbidity data. Evidence of genetic traits such as glucose-6-phosphate dehydrogenase deficiency and ovalocytosis was analyzed. Antibody prevalence was high, with 79% and 84% for CS protein and SPf66, respectively, while T cell proliferation was infrequent and low, with 14% and 12% responders, respectively. Anti-CS protein antibodies increased with age but showed no association to malaria indices or morbidity. No protective value was observed with T cell responses or with humoral response to SPf66. These results provide a first description of naturally developed immunity against SPf66 and suggest further studies in to fully understand the mechanism of immunity against this antigen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9637
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
356-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7943557-Adolescent,
pubmed-meshheading:7943557-Adult,
pubmed-meshheading:7943557-Aged,
pubmed-meshheading:7943557-Animals,
pubmed-meshheading:7943557-Antibodies, Protozoan,
pubmed-meshheading:7943557-Cross-Sectional Studies,
pubmed-meshheading:7943557-Female,
pubmed-meshheading:7943557-Glucosephosphate Dehydrogenase Deficiency,
pubmed-meshheading:7943557-Humans,
pubmed-meshheading:7943557-Immunity, Cellular,
pubmed-meshheading:7943557-Longitudinal Studies,
pubmed-meshheading:7943557-Lymphocyte Activation,
pubmed-meshheading:7943557-Malaria,
pubmed-meshheading:7943557-Malaria Vaccines,
pubmed-meshheading:7943557-Male,
pubmed-meshheading:7943557-Middle Aged,
pubmed-meshheading:7943557-Morbidity,
pubmed-meshheading:7943557-Papua New Guinea,
pubmed-meshheading:7943557-Parasitemia,
pubmed-meshheading:7943557-Plasmodium falciparum,
pubmed-meshheading:7943557-Prevalence,
pubmed-meshheading:7943557-Protozoan Proteins,
pubmed-meshheading:7943557-Recombinant Proteins,
pubmed-meshheading:7943557-Seasons
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
Assessment of the humoral and cell-mediated immunity against the Plasmodium falciparum vaccine candidates circumsporozoite protein and SPf66 in adults living in highly endemic malarious areas of Papua New Guinea.
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pubmed:affiliation |
Papua New Guinea Institute of Medical Research, Madang.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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