Linked Life Data

7942048

Source:http://linkedlifedata.com/resource/pubmed/id/7942048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-11-17
pubmed:abstractText
Recent evidence suggests that there is a close correlation between the physiological responses to muscle chemoreflex and the decrease in intracellular pH during ischaemia after handgrip. This study evaluated whether the relationship is linear or has an apparent threshold. We measured muscle cellular pH through phosphorous nuclear magnetic resonance spectroscopy (31P-NMR), mean arterial blood pressure (MAP) and heart rate (HR) during ischaemia after sustained handgrip exercise at 50% of maximum voluntary contraction (MVC). Contraction was sustained for 15, 30, 45 and 60 s, followed by 2 min of circulatory arrest, respectively. Muscular pH during the ischaemia decreased linearly with increasing contraction time, from the base-line level of 7.11 +/- 0.03 units (U) to 6.98 +/- 0.03, 6.90 +/- 0.04, 6.72 +/- 0.06 and 6.54 +/- 0.06 U after 15-, 30, 45-, and 60-s contractions, respectively. The MAP was 86 +/- 2 mmHg at rest and did not change during the ischaemia after 15- and 30-s contractions. However, it significantly increased to 95 +/- 2 and 107 +/- 2 mmHg, after 45- and 60-s contractions, respectively. These data indicate that the relationship between MAP and pH is not a single linear relationship, showing one breaking point around the pH of 6.90 units. It suggests that the muscle chemoreflex has a clear threshold around 6.90 units of muscle pH, and below this pH, MAP increased linearly with decreasing muscle cellular pH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Relationship between mean arterial pressure and muscle cell pH during forearm ischaemia after sustained handgrip.
pubmed:affiliation
Department of Biomechanics and Physiology, Faculty of Liberal Arts, Yamaguchi University, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't