| pubmed-article:7939408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0024267 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0020966 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:7939408 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7939408 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7939408 | pubmed:dateCreated | 1994-10-24 | lld:pubmed |
| pubmed-article:7939408 | pubmed:abstractText | Parameters of the virus-specific T-cell response were analysed in order to dissect the contribution of CD4+ and CD8+ T cells to cell-mediated immunity to lymphocytic choriomeningitis virus. In MHC class II deficient mice, initial T-cell responsiveness was not impaired, but virus clearance was delayed, and virus-specific Td activity declined more rapidly. Furthermore, class I restricted Tc memory appeared to be impaired in these mice. To directly evaluate the role of CD4+ cells in virus clearance and T-cell mediated inflammation, MHC class I deficient mice were also studied. No virus-specific delayed-type hypersensitivity reaction was detected following infection of the footpad, and only a few mice died from intracerebral challenge. However analysis of markers of T-cell activation as well as direct evaluation of CSF inflammation unveiled a low degree of T-cell activation and a chronic cellular exudate. This low-grade response was associated with some degree of virus control as organ titres were lower in these animals than in matched T-cell deficient nu/nu mice or class I deficient mice treated with anti-CD4 monoclonal antibody. This confirms that CD4+ cells are not needed to induce a virus-specific CD8+ T-cell response, but our findings strongly suggest that CD4+ T cells are critical for maintaining full antiviral immunity. Furthermore, CD4+ T cells per se have a low potential for mediating virus-specific inflammation that is associated with a low degree of virus control. | lld:pubmed |
| pubmed-article:7939408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7939408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939408 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7939408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7939408 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7939408 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:7939408 | pubmed:author | pubmed-author:MarkerOO | lld:pubmed |
| pubmed-article:7939408 | pubmed:author | pubmed-author:ThomsenA RAR | lld:pubmed |
| pubmed-article:7939408 | pubmed:author | pubmed-author:ChristensenJ... | lld:pubmed |
| pubmed-article:7939408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7939408 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:7939408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7939408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7939408 | pubmed:pagination | 373-82 | lld:pubmed |
| pubmed-article:7939408 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7939408 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7939408 | pubmed:articleTitle | The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice. | lld:pubmed |
| pubmed-article:7939408 | pubmed:affiliation | Institute of Medical Microbiology and Immunology, University of Copenhagen, Panum Institute, Denmark. | lld:pubmed |
| pubmed-article:7939408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7939408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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