Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-10-24
|
| pubmed:abstractText |
Parameters of the virus-specific T-cell response were analysed in order to dissect the contribution of CD4+ and CD8+ T cells to cell-mediated immunity to lymphocytic choriomeningitis virus. In MHC class II deficient mice, initial T-cell responsiveness was not impaired, but virus clearance was delayed, and virus-specific Td activity declined more rapidly. Furthermore, class I restricted Tc memory appeared to be impaired in these mice. To directly evaluate the role of CD4+ cells in virus clearance and T-cell mediated inflammation, MHC class I deficient mice were also studied. No virus-specific delayed-type hypersensitivity reaction was detected following infection of the footpad, and only a few mice died from intracerebral challenge. However analysis of markers of T-cell activation as well as direct evaluation of CSF inflammation unveiled a low degree of T-cell activation and a chronic cellular exudate. This low-grade response was associated with some degree of virus control as organ titres were lower in these animals than in matched T-cell deficient nu/nu mice or class I deficient mice treated with anti-CD4 monoclonal antibody. This confirms that CD4+ cells are not needed to induce a virus-specific CD8+ T-cell response, but our findings strongly suggest that CD4+ T cells are critical for maintaining full antiviral immunity. Furthermore, CD4+ T cells per se have a low potential for mediating virus-specific inflammation that is associated with a low degree of virus control.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0300-9475
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
373-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7939408-Animals,
pubmed-meshheading:7939408-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7939408-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7939408-Disease Susceptibility,
pubmed-meshheading:7939408-Female,
pubmed-meshheading:7939408-Histocompatibility Antigens Class I,
pubmed-meshheading:7939408-Histocompatibility Antigens Class II,
pubmed-meshheading:7939408-Hypersensitivity, Delayed,
pubmed-meshheading:7939408-Immunity, Cellular,
pubmed-meshheading:7939408-Immunophenotyping,
pubmed-meshheading:7939408-Lymphocyte Activation,
pubmed-meshheading:7939408-Lymphocytic Choriomeningitis,
pubmed-meshheading:7939408-Lymphocytic choriomeningitis virus,
pubmed-meshheading:7939408-Mice,
pubmed-meshheading:7939408-Mice, Inbred C57BL,
pubmed-meshheading:7939408-Mice, Nude,
pubmed-meshheading:7939408-Spleen,
pubmed-meshheading:7939408-beta 2-Microglobulin
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice.
|
| pubmed:affiliation |
Institute of Medical Microbiology and Immunology, University of Copenhagen, Panum Institute, Denmark.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|