Linked Life Data

7938911

Source:http://linkedlifedata.com/resource/pubmed/id/7938911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-11-1
pubmed:abstractText
The aim of the present study was to determine whether heat acclimation increases whole-body sensitivity to insulin. Male Wistar rats were kept at 34 degrees C for 2 weeks (HA group). Warm-acclimated rats (WA group) at 25 degrees C served as controls. The glucose infusion rate (GIR) was assessed as an index of in vivo insulin sensitivity, using a hyperinsulinemic euglycemic clamp technique. Moreover, the 125I-insulin binding capacity to purified insulin receptor preparations from m. gastrocnemius of rats after 1, 7, or 14 days of heat exposure was examined. Mean GIR values of HA group were slightly higher than those of WA group, but not significant. The great deviation of the HA group, however, appeared to exist. About half of HA rats showed markedly high GIR values (p < 0.01 vs. WA group). Mean GIR value of the remaining HA rats were significantly (p < 0.05) lower than those of the WA group. Likewise, the binding capacity to 125I-insulin was not significantly different among the periods of time of heat exposure, and the deviation went on increasing from 1 to 14 days. These results suggest that there is a wide individual difference between the changes in glucose metabolism under heat exposure. In view of such results, there appears to be a great need for further studies on the factors affecting the variation of insulin action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Is heat acclimation able to increase whole-body sensitivity to insulin?
pubmed:affiliation
Japan College of Social Work, Tokyo.
pubmed:publicationType
Journal Article, Comparative Study