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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1994-10-27
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pubmed:abstractText |
Atherosclerosis is a complex disease with both genetic and environmental determinants. Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to atherosclerosis. In order to assess the role of human apolipoprotein (hApo) A-I and high density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing the hApo A-I gene were crossed with Apo E-deficient mice. Apo E-/-, hApo A-I mice with two-fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less fibroproliferative lesions by 8 months of age. A strong reciprocal relationship between HDL cholesterol levels and atherosclerosis was found with HDL levels accounting for 78% of the observed variance in mean lesion area. The effect of HDL on atherosclerosis resistance was independent of non-HDL cholesterol.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1411543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1423598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1584779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1898657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1901417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-1910153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-2318976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-2495286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-2642759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-2677733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-3426656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-3841001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-6392459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-6800349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-7078608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-8245716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-8274468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-8274470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-8332912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937814-8413656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9607-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7937814-Aging,
pubmed-meshheading:7937814-Animals,
pubmed-meshheading:7937814-Aorta,
pubmed-meshheading:7937814-Apolipoprotein A-I,
pubmed-meshheading:7937814-Apolipoproteins E,
pubmed-meshheading:7937814-Arteriosclerosis,
pubmed-meshheading:7937814-Cholesterol,
pubmed-meshheading:7937814-Cholesterol, HDL,
pubmed-meshheading:7937814-Crosses, Genetic,
pubmed-meshheading:7937814-Gene Expression,
pubmed-meshheading:7937814-Humans,
pubmed-meshheading:7937814-Lipoproteins, LDL,
pubmed-meshheading:7937814-Mice,
pubmed-meshheading:7937814-Mice, Inbred C57BL,
pubmed-meshheading:7937814-Mice, Inbred CBA,
pubmed-meshheading:7937814-Mice, Transgenic,
pubmed-meshheading:7937814-Muscle, Smooth, Vascular,
pubmed-meshheading:7937814-Muscle Development
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pubmed:year |
1994
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pubmed:articleTitle |
Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.
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pubmed:affiliation |
Rockefeller University, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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