rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1977-2-16
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pubmed:abstractText |
This paper describes the histopathology of chronic tuberculin-type hypersensitivity reactions in the normal canine and malignant human prostate. Seven dogs were sensitized by injection of Freund's complete adjuvant and the histological response to the subsequent intra-prostatic injection of 6 mg tuberculin PPD was documented. A chronic mononuclear cell prostatis persisted for 4 weeks and was accompanied by paracortical distension and follicular hyperplasia in regional lymph nodes. Six patients with carcinoma of the prostate were given multiple intraprostatic injections of BCG, which induced a chronic mononuclear cell prostatitis with some evidence of tumour-cell necrosis. The study indicated that the prostate can support chronic cell-mediated allergic reactions to extrinsic antigens and that intra-prostatic injections of BCG can be administered without harmful effects to patients with malignant prostatic disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0009-9104
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-47
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:793748-Adenocarcinoma,
pubmed-meshheading:793748-Animals,
pubmed-meshheading:793748-BCG Vaccine,
pubmed-meshheading:793748-Dogs,
pubmed-meshheading:793748-Humans,
pubmed-meshheading:793748-Hypersensitivity, Delayed,
pubmed-meshheading:793748-Immunity, Cellular,
pubmed-meshheading:793748-Lymphocytes,
pubmed-meshheading:793748-Male,
pubmed-meshheading:793748-Mycobacterium bovis,
pubmed-meshheading:793748-Prostate,
pubmed-meshheading:793748-Prostatic Neoplasms,
pubmed-meshheading:793748-Prostatitis,
pubmed-meshheading:793748-Tuberculin
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pubmed:year |
1976
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pubmed:articleTitle |
Experimental cellular allergic reactions in normal canine and malignant human prostate.
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pubmed:publicationType |
Journal Article
|