Linked Life Data

7936073

Source:http://linkedlifedata.com/resource/pubmed/id/7936073

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-11-17
pubmed:abstractText
The role of coxsackie virus infection in the pathogenesis of idiopathic inflammatory muscle disease (IIMD) has been investigated by many workers with conflicting results. This study uses in situ hybridization, with digoxigenin-labelled oligonucleotide probes complementary to the coxsackie B virus genome, to investigate the presence of virus RNA in muscle biopsies from 26 patients with IIMD. In the five cases of inclusion body myositis studied, there was focal probe-binding to nuclei and cytoplasm, and in nine cases probe-binding to mast cells was seen. In both of these instances probe-binding was non-specific and not due to hybridization. None of the cases showed the presence of coxsackie virus RNA within muscle and it is concluded that lytic infection of myocytes by coxsackie virus does not occur in IIMD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0305-1846
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Absence of Coxsackie viruses in idiopathic inflammatory muscle disease by in situ hybridization.
pubmed:affiliation
Department of Neuropathology, Frenchay Hospital, Bristol, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't