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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6499
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pubmed:dateCreated |
1994-11-8
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pubmed:abstractText |
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
371
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
674-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7935812-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7935812-Animals,
pubmed-meshheading:7935812-Base Sequence,
pubmed-meshheading:7935812-Cell Adhesion,
pubmed-meshheading:7935812-Cell Line,
pubmed-meshheading:7935812-Collagenases,
pubmed-meshheading:7935812-Enzyme Activation,
pubmed-meshheading:7935812-Extracellular Matrix Proteins,
pubmed-meshheading:7935812-Fibroblast Growth Factor 2,
pubmed-meshheading:7935812-Fibronectins,
pubmed-meshheading:7935812-Gene Products, tat,
pubmed-meshheading:7935812-HIV-1,
pubmed-meshheading:7935812-Humans,
pubmed-meshheading:7935812-Matrix Metalloproteinase 9,
pubmed-meshheading:7935812-Mice,
pubmed-meshheading:7935812-Mice, Inbred BALB C,
pubmed-meshheading:7935812-Mice, Nude,
pubmed-meshheading:7935812-Molecular Mimicry,
pubmed-meshheading:7935812-Molecular Sequence Data,
pubmed-meshheading:7935812-Palatine Tonsil,
pubmed-meshheading:7935812-Sarcoma, Kaposi,
pubmed-meshheading:7935812-Skin,
pubmed-meshheading:7935812-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1994
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pubmed:articleTitle |
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma.
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pubmed:affiliation |
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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