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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-11-9
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen with potent angiogenic properties. In tumors, VEGF has been localized to the most necrotic and ischemic areas of the tissues, suggesting that local hypoxia is a potent inducer of VEGF production. Initial experiments in vitro confirmed the stimulatory effect of hypoxia on VEGF expression. The extent of this response and the mechanisms involved in oxygen sensing are poorly characterized.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0023-6837
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
374-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7933988-Anemia,
pubmed-meshheading:7933988-Animals,
pubmed-meshheading:7933988-Anoxia,
pubmed-meshheading:7933988-Cells, Cultured,
pubmed-meshheading:7933988-Cobalt,
pubmed-meshheading:7933988-Endothelial Growth Factors,
pubmed-meshheading:7933988-Endothelium, Vascular,
pubmed-meshheading:7933988-Fibroblasts,
pubmed-meshheading:7933988-Gene Expression,
pubmed-meshheading:7933988-Isomerism,
pubmed-meshheading:7933988-Lymphokines,
pubmed-meshheading:7933988-Male,
pubmed-meshheading:7933988-Nucleic Acid Hybridization,
pubmed-meshheading:7933988-RNA, Messenger,
pubmed-meshheading:7933988-Rats,
pubmed-meshheading:7933988-Rats, Wistar,
pubmed-meshheading:7933988-Ribonucleases,
pubmed-meshheading:7933988-Tissue Distribution,
pubmed-meshheading:7933988-Vascular Endothelial Growth Factor A,
pubmed-meshheading:7933988-Vascular Endothelial Growth Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.
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pubmed:affiliation |
Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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