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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1977-1-25
|
| pubmed:abstractText |
Organ-specific, species non-specific anti-pancreatic cellular immunity has been reported as a feature associated with juvenile diabetes of short duration. In order to further elucidate a possible causal relation between autoimmunity and juvenile diabetes morphological studies were made on an autopsy material from 12 juvenile onset diabetics, dying within 1 year after the onset of the disease. Each patient was compared with 2 age and sex matched controls. In the group of patients the islets of Langerhans showed the following characteristics: 1. The B cells were degranulated and present in reduced number, 2. The A cells appeared normal, 3. A lymphocytic, non-cicatricial insulitis was detected in 50% of the patients. Those findings were correlated with animal experiments, in which rats and mice were immunized with A: heterologous and homologous preparations of endocrine pancreas, in complete Freunds' adjuvant, B: heterologous and homologous insulin in complete Freunds' adjuvant, and C: complete Freunds' adjuvant. Only animals of group A developed spleen cell migration tests positive to the pancreatic preparations, lymphocytic infiltrations of the islets and degranulation of the B cells. In addition, the B cells showed ultrastructural signs of degeneration. The morphological changes were reversible and were accompanied by a transient reduction in glucose tolerance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-9750
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
205
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
129-37
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:793275-Adolescent,
pubmed-meshheading:793275-Adult,
pubmed-meshheading:793275-Animals,
pubmed-meshheading:793275-Autoimmune Diseases,
pubmed-meshheading:793275-Child,
pubmed-meshheading:793275-Child, Preschool,
pubmed-meshheading:793275-Diabetes Mellitus, Type 1,
pubmed-meshheading:793275-Disease Models, Animal,
pubmed-meshheading:793275-Female,
pubmed-meshheading:793275-Glucose Tolerance Test,
pubmed-meshheading:793275-Humans,
pubmed-meshheading:793275-Immunity, Cellular,
pubmed-meshheading:793275-Immunization,
pubmed-meshheading:793275-Insulin,
pubmed-meshheading:793275-Islets of Langerhans,
pubmed-meshheading:793275-Lymphocytes,
pubmed-meshheading:793275-Male,
pubmed-meshheading:793275-Mice,
pubmed-meshheading:793275-Pancreatitis,
pubmed-meshheading:793275-Rats
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Autoimmune insulitis. Pathological findings in experimental animal models and juvenile diabetes mellitus.
|
| pubmed:publicationType |
Journal Article
|