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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017263,
umls-concept:C0021756,
umls-concept:C0025936,
umls-concept:C0034790,
umls-concept:C0037993,
umls-concept:C0039194,
umls-concept:C0087140,
umls-concept:C0108779,
umls-concept:C0185117,
umls-concept:C0332120,
umls-concept:C0879590,
umls-concept:C0936012,
umls-concept:C1627358,
umls-concept:C1948023,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
1994-11-10
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pubmed:abstractText |
Effects of the deregulated c-fos gene product on IL-2 expression were studied in splenic T cells from c-fos transgenic (H2-c-fos) mice. IL-2 gene expression and IL-2 production by H2-c-fos T cells stimulated with immobilized anti-CD3 Abs were enhanced and prolonged as compared with those by control T cells. Activator protein-1 activity in nuclear extract from the H2-c-fos T cells was also higher than that from the control cells. There was no significant difference in the activity of other transcription factors including IL-2 kappa B, NFAT, and Oct-1, between the H2-c-fos and the control T cells. However, activity of a negative regulatory element binding factor (NRE-A) in the H2-c-fos T cells was much lower than that in the control cells. These results suggest that c-Fos/activator protein-1 is a major regulatory factor for IL-2 gene expression in splenic T cells activated through the TCR/CD3 complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3485-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7930571-Animals,
pubmed-meshheading:7930571-Antigens, CD3,
pubmed-meshheading:7930571-Base Sequence,
pubmed-meshheading:7930571-DNA-Binding Proteins,
pubmed-meshheading:7930571-Gene Expression Regulation,
pubmed-meshheading:7930571-Genes, fos,
pubmed-meshheading:7930571-Genes, jun,
pubmed-meshheading:7930571-Interleukin-2,
pubmed-meshheading:7930571-Lymphocyte Activation,
pubmed-meshheading:7930571-Mice,
pubmed-meshheading:7930571-Mice, Inbred C57BL,
pubmed-meshheading:7930571-Mice, Transgenic,
pubmed-meshheading:7930571-Molecular Sequence Data,
pubmed-meshheading:7930571-Oligonucleotide Probes,
pubmed-meshheading:7930571-RNA, Messenger,
pubmed-meshheading:7930571-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7930571-Spleen,
pubmed-meshheading:7930571-T-Lymphocytes,
pubmed-meshheading:7930571-Transcription Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Analysis of IL-2 gene regulation in c-fos transgenic mice. Evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex.
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pubmed:affiliation |
Department of Immunology, ICMR, Kobe University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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